A new treatment is being researched for celiac disease that will include an oral medication called Larazati. Clinical trials have just been completed and show promising results.
The studywas being completed to:
evaluate the efficacy of multiple dose levels of [Larazati] AT-1001 in preventing intestinal permeability changes induced by a 6-week gluten challenge.
The 184 participants remained on a gluten free diet but along with their determined dosage ofLarazati(or the placebo) were given a pill that contained 900mg of gluten. The medication was taken orally 15 minutes before each meal (breakfast, lunch and dinner) as well as the gluten capsule.
The medication is said to strengthen the junctions that hold the intestine together which then blocks the gluten from going into the tissue and damaging it.
The trials have also showed some promise in repairing already damaged tissue.The medication is not being hailed as a cure for celiac disease but as another way to help those affected everyday by protecting from those times when they accidentally come into contact with gluten.
The trials are still ongoing to look further into the safety and dosage.
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{ 4 comments… read them below or add one }
Wow! It sure would be awesome if they could help us with the whole cross-contamination issue. Seems like I've gotten glutened several times over the past couple of weeks and I can't figure out the source. Something like this medication sure would be nice! I sometime use Glutenese, which helps, too.
I want to see some very, very long term research on these types of medications. A celiac not following a GF diet is at risk of developing other autoimmune disorders and has a much higher incidence rate of cancers over the normal population. I am not willing to mask symptoms and risk these things. I want every symptom to scream at me to not eat gluten containing products so that I can lower my risks to that of the rest of the population. The GF diet is not that bad and I'd rather be on a strict GF diet and not develop cancer.
From what I have read about this medication it is not being marketed or studied as a way to go off the gluten free diet – it is more so a preventative measure. If someone who is on a strict GF diet accidentally comes into contact with gluten – the medication is aimed to reduce the intestinal damage that would occur – then reducing the risk of cancers and celiac symptoms.
I do agree though – the gf diet is not that bad. For people like Kim (and myself) who are having active celiac symptoms but are unsure of what the source is – this medication could be a huge help!
Thanks for sharing your comments! I love hearing from you.
I totally agree; gluten free – I suffer – gluten somehow in the diet – I suffer. THe anemia is the killer for me, and as a child was treated with blod transfusions for this. I absorb very little nutrients from anything, yet one would think I would be thin as a rake. Not so. I am 54 look health and have more than a few extra pounds and had 3 very healthy babies. Being celiac patient with some of the other add on conditons is as weird as my husband having been diagnosed at he age of 35 with systemic Lupus and avery horrid case. We certainly didn't go looking for illness and traveled the world as well. Live took a turn for both of us. It is daunting. I have been hospitalized 6 times with severe respiratory/cardiac related celiac disorder since 2001. Now everything has settled down as long as I take supplements as well. Stress does not help either, nor does it help anything. Hope this Lazarati medication comes to fruition for all. And doesn't cost a fortune!!